Tuesday, January 19, 2010

Filipino discovers new vaccine vs. malaria

(globalnation.inquirer.net)



MANILA, Philippines—Rhoel Dinglasan, an entomologist and biologist from John Hopkins University, is rocking the science world with his discovery of a new vaccine against malaria.

It prevents mosquitoes from spreading malaria if they bite someone who’s been inoculated with the vaccine, and brings the medical world a step closer to eradicating the disease.

Dinglasan’s discovery was recently featured in the Health and Science section of TIME magazine. Here are excerpts from the article.

“Traditional vaccines work by introducing a killed or weakened version of a disease into the body, where the immune system spots it and cranks out antibodies against it. Then, if a wild strain of the pathogen comes along later—one that has the power to sicken or kill—the body is ready for it. The new approach is different. Developed by Rhoel Dinglasan, an entomologist and biologist at Johns Hopkins University Hospital, it would instead work within the mosquito gut.

Dinglasan has found an antigen, called AnAPN1, that causes humans to create antibodies that prevent transmission of malaria by mosquitoes. Get enough of these antibodies into mosquitoes, and you lock the disease up there and prevent it from infecting us.

Sounds good, but how do you implement such a strategy? You can hardly vaccinate the mosquitoes themselves. Instead, you put the AnAPN1 into their food source: us. A mosquito that bites an inoculated person would pick up the antibodies and then be sidelined from the malaria-transmission game.
The new vaccine is not the first TBV attempted. Previous versions used not AnAPN1 but parts of the malaria parasite to generate human immune responses.

Unfortunately, two vaccine candidates using that approach unexpectedly caused some skin disorders when tested in humans in 2008, prompting a need for further research. And even without that side effect, using antigens from the malaria parasite would require multiple vaccines to fight the many different strains of malaria.”

Friday, January 8, 2010

The Good and Bad Sides of Herbal Medicines

This is an article from Neal H. Cruz's "As I See It" - The Philippine Daily Inquirer
Friday, January 8, 2010



WE HAVE RECEIVED MANY COMPLAINTS about herbal medicines being advertised and sold. We have also been offered these herbs, complete with anecdotal stories about the scores of people that the “miraculous” herbs have “cured.” Some time ago, I read a story in the papers that Health Secretary Francisco Duque had ordered the Food and Drug Administration (FDA) to investigate the claims of those companies manufacturing, advertising and selling herbal medicines to guide the public. The people may be misled by the extravagant claims, he said. At a forum of the Kapihan sa Manila the FDA head assured me that they were testing the efficacy of the herbal medicines being sold. That was a long time ago, but until now the FDA has not released any of its findings, if any.

The rise of the herbal medicines started during the term of a previous health secretary who used to be a country doctor. Because of the high cost of medicines, his administration encouraged the sale of medicinal herbs which can be had for free in the countryside.

Of course, herbal medicines have been used in China for decades but it is still new in the Philippines.
The herbal revolution started with ampalaya leaves as a “cure” against diabetes, supposedly after a test made by a doctor. The health department seized on this and immediately boarded the ampalaya bandwagon. It turned out that the sampling was very limited and the ampalaya leaves came only from a small farm on Mt. Makiling. And there was—and still is—no proof that they can cure diabetes. I asked endocrinologists about this and they all shook their heads.




But there was no stopping the herbal bandwagon. Other herbal medications purporting to “cure” the most deadly diseases: cancer, heart disease, high-blood pressure, diabetes, arthritis, name the disease and there is a herbal medicine for it.

The public has looked to the FDA and the health department to guide them on the use of herbals. But there was no such guidance, and there being none, not even any warnings, the people embraced the sales pitch of the herbal companies. Companies producing, promoting and selling herbal medicines sprouted like mushrooms. And judging from their frequent newspaper advertisements, television commercials using celebrity endorsers, and giant billboards, these companies must be raking it in. After all, what were they selling but leaves and herbs that they gather almost free from the countryside. Yet these are sold at handsome prices in different forms: capsules, tablets, liquid, tea leaves, etc.

Every few months, a new flavor of the month, a “miraculous” plant from some exotic place, emerges and is promoted by their sellers like they were the Black Nazarene of Quiapo. One time it was mahogany seeds, another time it was an exotic fruit whose name I cannot remember. After a few months, these “miraculous” cures were forgotten, only to be replaced by others.

It turned out that some of these are toxic. A journalist friend (of all people) habitually chewed on mahogany seeds. It lowered his blood pressure, he said. The mahogany seeds did not only lower his blood pressure, it stopped his heart. The seeds were toxic, the health department found out later. But it was too late. He was dead.

My sister-in-law was diagnosed with cancer of the pancreas and she was told to undergo chemotherapy. Instead, she was persuaded by a friend to take a herbal concoction. In the beginning, she claimed she was feeling better, but she died soon after. Of course, it could have been the cancer that killed her but that is the trouble with herbals. Because of the extravagant claims of their promoters without any scientific basis, many patients forego the advice of doctors and take their chances with herbals.

It is the responsibility of the government to guide the people on whether or not certain medications are good or bad for their health. We have the FDA for that. But the herbal companies escape government scrutiny by putting on the packages of their herbal medicines, “No therapeutic claims,” meaning they are not making any claims that their herbs have any therapeutic value.

But that is exactly what their advertisements and commercials and literature do: they claim that their herbs cure any disease known to man: cancer, heart disease, asthma, diabetes, high blood pressure, rheumatism, fever, diarrhea, women’s diseases, etc. They were like the “snake oil” of old that traveling salesmen sold door to door after performing some magic tricks and acrobatic acts in the street to attract a crowd. Actually, the snake oil was nothing but colored coconut oil scented with menthol and had no curative value at all.
The FDA claims it has no jurisdiction over herbals because they are not medicines but food supplements. But they are being sold as medicines and in capsule, tablet, liquid forms or as tea. They are sold in drug stores; they are packaged as regular medicines; they are endorsed by doctors and other celebrities.

There should be a law to punish any endorser of a medicine, herbal or regular, that brings harm to any patient.

The DOH and FDA are being negligent by not investigating the herbals more closely. They should outlaw the sale of these herbals until each and every one of them has been tested as to the truth of their claims. And if any of them harms a patient, the company and endorsers should be punished and made to pay damages to the patient or his family.

These irresponsible herbal companies are happily raking it in without facing any consequences if they made a mistake. It is time we changed that and protected the public.

Monday, January 4, 2010

"Bulilit Subalit Malupit"

I've played a hefty number of games to date and can't deny the fact that my favorite gaming genre is MMORPG (massive multiplayer online role playing games). Currently, I'm glued to Run Up's Luna Online


(image from Run Up website)

Luna Online is another 3D MMO published by the people at gpotato (who were known for bringing you Fly for Fun (Flyff) and Rappelz) with bright, anime-inspired graphics and an emphasis on socialization. Players choose from three primary classes, and can then branch out into over forty available classes as they level. Luna Online allows players to form Families and purchase farmland to cultivate together

Story is about elves and humans and the struggle for Blueland's Survival.

Graphics: very cute 3D graphics... This can be seen as an up or a down. Personally; this game had been a pleasant experience for me. The characters are extremely cute, it makes you want to squeeze them! On the other hand; it might be TOO cute.. it's like Ragnarok online... only 3D and... cuter (imho)

Classes: You get to choose from 3 classes - 2 races.. Human/Elf Fighter .... Human/Elf Mage... Human/Elf Rouge... then the job tree branches out into around 40... some of which can only be open to a specific race.. (example.. only an elf mage can reach elemental master job... and only a human rouge can reach blade taker)

Controls: The controls are very standard to its game play. Like most MMOs, you use the numeric keys 1 2 3 to 0 .... and be able to use another slot by holding the control key and pressing the numeric key... which gives you 20 skills in one screen. This is a point and click game, which might seem boring to some... But the game play is just so smooth that you might even compensate for the fact that it really is a point and click.

Combat: For Ragnarok Online lovers, this game will not disappoint you! The first time I played this game and got 20 levels through, advancing my class to the next.. and since there are a lot of jobs/classes to choose from... you get to enjoy your respective roles most of the time. (as usual, I chose another support class --- Mage-Cleric... currently I'm a level 40 priest)

The game heavily revolves around quests. There are a nice amount of quests available and it helps earn money and experience quickly. Its a good start, but once the number of quests starts to go down, it begins to get a bit difficult to grind. Luckily grinding isn't that bad for the most part. Its fairly simple to level up if you choose to until later on (say the 50s). Once you get through a good amount of the game its either something you enjoy or hate. Experience is based on your level compared to the mob's level. Ideally you want to be 3-5 levels below the monster you're training on.




Features: Guilds, Families, Farming.... and Dating! Yes! Dating... the game lets you input your personal information... your age, location, gender... and... of course the things you're looking for in another partner..



Concerns:  MMORPGs are dominated by males so people who play this game for the "Dating Feature" will likely be looking at dating service with 10% female and 90% males, something like that. Another is that there are already a lot of online games available and the game might not be able to catch up to the "population" of other games.. the most popular not even being online (DotA).

Final Note: Luna Online is a game that tries to focus on character development rather than the story or development of game characters through quest. This is something that some people might like while many who are not use to it might dislike it. The skill system is something that is rare, but it lacks a more free mix and match system that might be preferred over this semi-free system. Grinding can get a bit heavy later on but its very light in the beginning. For those who want to get deeply involved in the game, they can while those who don't want to can stay away from those features and still enjoy the game.

I give it a 7/10

Friday, January 1, 2010

Merry Christmas and a Happy New Year


Merry Christmas


and a Joyous New Year!


What can be said in New Year rhymes,

That's not been said a thousand times?

The new years come, the old years go,

We know we dream, we dream we know.

We rise up laughing with the light,

We lie down weeping with the night.

We hug the world until it stings,

We curse it then and sigh for wings.

We live, we love, we woo, we wed,

We wreathe our prides, we sheet our dead.

We laugh, we weep, we hope, we fear,

And that's the burden of a year.
                                                                                    --- Ella Wilcox

More Pictures in My Facebook